Identification of residues of SARS-CoV nsp1 that differentially affect inhibition of gene expression and antiviral signaling.
An epidemic of Severe Acute Respiratory Syndrome (SARS) led to the identification of an associated coronavirus, SARS-CoV.This virus evades the host here innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling.Thus, nsp1